Centrally located in the eastern half of the US with excellent transportation infrastructure, travel to the Tri-Cities has two major Interstate Highways (I-81 and I-26) intersect within the region, while I-40, I-77 and I-75 are nearby.
The Tri-Cities Regional Airport (TRI) has non-stop service to Atlanta, Cincinnati, Charlotte, Detroit, Memphis, Ft. Lauderdale, Tampa and Orlando. The airport is serviced by Delta, US Airways, Northwest, and Allegiant Air.
Distance from the Tri-Cities Regional Airport
| City | Miles |
|---|---|
| Asheville, NC | 76 |
| Knoxville, TN | 100 |
| Greenville, SC | 138 |
| Charlotte, NC | 170 |
| Greensboro, NC | 205 |
| Nashville, TN | 279 |
| Louisville, KY | 303 |
| Atlanta, GA | 312 |
| Charleston, SC | 342 |
| Myrtle Beach, SC | 380 |
| Washington, DC | 392 |
| Indianapolis, IN | 415 |
| Norfolk, VA | 432 |
| Virginia Beach, VA | 446 |
| Memphis, TN | 490 |
| Jacksonville, FL | 516 |
| Philadelphia, PA | 532 |
| Chicago, IL | 596 |
| New York, NY | 613 |
