Centrally located in the eastern half of the US with excellent transportation infrastructure, travel to the Tri-Cities has two major Interstate Highways (I-81 and I-26) intersect within the region, while I-40, I-77 and I-75 are nearby.

The Tri-Cities Regional Airport (TRI) has non-stop service to Atlanta, Cincinnati, Charlotte, Detroit, Memphis, Ft. Lauderdale, Tampa and Orlando. The airport is serviced by Delta, US Airways, Northwest, and Allegiant Air.

Distance from the Tri-Cities Regional Airport

City Miles
Asheville, NC 76
Knoxville, TN 100
Greenville, SC 138
Charlotte, NC 170
Greensboro, NC 205
Nashville, TN 279
Louisville, KY 303
Atlanta, GA 312
Charleston, SC 342
Myrtle Beach, SC 380
Washington, DC 392
Indianapolis, IN 415
Norfolk, VA 432
Virginia Beach, VA 446
Memphis, TN 490
Jacksonville, FL 516
Philadelphia, PA 532
Chicago, IL 596
New York, NY 613