The Tri-Cities region is centrally located in the eastern United States with strong transportation access. Major interstates including I-81 and I-26 run through the region, with I-40, I-77, and I-75 nearby.

The Tri-Cities Regional Airport (TRI) offers nonstop service to several major cities and is served by multiple commercial airlines.

Distance from Tri-Cities Regional Airport

City Miles
Asheville, NC76
Knoxville, TN100
Greenville, SC138
Charlotte, NC170
Greensboro, NC205
Nashville, TN279
Louisville, KY303
Atlanta, GA312
Charleston, SC342
Myrtle Beach, SC380
Washington, DC392
Indianapolis, IN415
Norfolk, VA432
Virginia Beach, VA446
Memphis, TN490
Jacksonville, FL516
Philadelphia, PA532
Chicago, IL596
New York, NY613